The spiritual meaning is what is most important and to use fermented corrupted grape juice to represent the blood of Jesus is wrong. Rom 14:21 It is good neither to eat flesh, nor to drink wine, nor any thing whereby thy brother stumbleth, or is offended, or is made weak.
Alcohol is proven to reduce your mental and physical wellbeing so i see it as sin. Your body is the temple of the Holy Spirit so don't corrupt it.
Joh_6:53 Then Jesus said unto them, Verily, verily, I say unto you, Except ye eat the flesh of the Son of man, and drink his blood, ye have no life in you.
Mat 26:26 And as they were eating, Jesus took bread, and blessed it, and brake it, and gave it to the disciples, and said, Take, eat; this is my body.
Mat 26:27 And he took the cup, and gave thanks, and gave it to them, saying, Drink ye all of it;
Mat 26:28 For this is my blood of the new testament, which is shed for many for the remission of sins.
Mat 26:29 But I say unto you, I will not drink henceforth of this fruit of the vine, until that day when I drink it new with you in my Father's kingdom.
Why use alcoholic wine if you can use unfermented wine and remember the meaning in the same way. Jesus is going to drink it with us in Heaven and i don't think it will be fermented and alcoholic in heaven.