No, no one is able to resist God's effectual grace. Nothing is impossible with God (Lk 1:37; 18:27). No man can thwart God's purposes (Job 42:2).
How much Calvinism have you been exposed to?
Romans One is a prime example of men having been drawn by God, and who rejected God after having God made real to them.
16 For I am not ashamed of the gospel, because it is the power of God
that brings salvation to everyone who believes: first to the Jew, then to
the Gentile. 17 For in the gospel the righteousness of God is revealed—
a righteousness that is by faith from first to last, just as it is written:
“The righteous will live by faith.”
18 The wrath of God is being revealed from heaven against all the
godlessness and wickedness of people, who suppress the truth by
their wickedness, 19 since what may be known about God is plain
to them, because God has made it plain to them. 20 For since the
creation of the world God’s invisible qualities—his eternal power
and divine nature—have been clearly seen, being understood
from what has been made, so that people are without excuse.
21 For although they knew God, they neither glorified him as God
nor gave thanks to him, but their thinking became futile and their
foolish hearts were darkened. 22 Although they claimed to be wise,
they became fools 23 and exchanged the glory of the immortal
God for images made to look like a mortal human being and birds
and animals and reptiles.
Calvinism was an attempt to make sense out of what it had not enough doctrine to check itself with.