God has made most people right-handed, so the mark on the right hand symbolizes a commitment to work for the Antichrist. People may think they are working for themselves, whereas they will be working for the Antichrist, who has full control of their lives.
There's Going To Be An End Times Persecution, The Beast And His Kingdom Are The Target Of God's Empowered (Two Witnesses)
The Great Tribulation Will Come Upon The Wicked World, While The (Sealed Church) Is Protected
The (Sealed Church) will be present on earth and protected, when wicked men are tormented 5 months, desiring to die as death flees
All saved believers are (Sealed) by God, Eph 1:13, 4:30
Ephesians 1:13KJV
13 In whom ye also trusted, after that ye heard the word of truth, the gospel of your salvation: in whom also after that ye believed,
ye were sealed with that holy Spirit of promise,
Ephesians 4:30KJV
30 And grieve not the holy Spirit of God, whereby
ye are sealed unto the day of redemption.
It Was Commanded, Only Those Without God's Seal, The Sealed Church Is Protected
Revelation 9:3-6KJV
3 And there came out of the smoke locusts upon the earth: and unto them was given power, as the scorpions of the earth have power.
4 And
it was commanded them that they should not hurt the grass of the earth, neither any green thing, neither any tree;
but only those men which have not the seal of God in their foreheads.
5 And to them it was given that they should not kill them, but that they should be tormented five months: and their torment was as the torment of a scorpion, when he striketh a man.
6 And
in those days shall men seek death, and shall not find it; and shall desire to die, and death shall flee from them.
Plagues upon The Beast and his Kingdom, a remake of Moses/Aaron against Pharaoh of Egypt
Revelation 11:3-6
3 And
I will give power unto my two witnesses, and they shall prophesy a thousand two hundred and threescore days, clothed in sackcloth.
4 These are the two olive trees, and the two candlesticks standing before the God of the earth.
5 And if any man will hurt them, fire proceedeth out of their mouth, and devoureth their enemies: and if any man will hurt them, he must in this manner be killed.
6
These have power to shut heaven, that it rain not in the days of their prophecy: and have power over waters to turn them to blood, and to smite the earth with all plagues, as often as they will.
Revelation 16:1-11KJV
1 And I heard a great voice out of the temple saying to the seven angels, Go your ways, and pour out the vials of the wrath of God upon the earth.
2 And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image.
3 And the second angel poured out his vial upon the sea; and it became as the blood of a dead man: and every living soul died in the sea.
4 And the third angel poured out his vial upon the rivers and fountains of waters; and they became blood.
5 And I heard the angel of the waters say, Thou art righteous, O Lord, which art, and wast, and shalt be, because thou hast judged thus.
6 For they have shed the blood of saints and prophets, and thou hast given them blood to drink; for they are worthy.
7 And I heard another out of the altar say, Even so, Lord God Almighty, true and righteous are thy judgments.
8 And the fourth angel poured out his vial upon the sun; and power was given unto him to scorch men with fire.
9 And men were scorched with great heat, and blasphemed the name of God, which hath power over these plagues: and they repented not to give him glory.
10 And the fifth angel poured out his vial upon the seat of the beast; and his kingdom was full of darkness; and they gnawed their tongues for pain,
11 And blasphemed the God of heaven because of their pains and their sores, and repented not of their deeds.