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I just prayed for your Grandma.
Sometimes there are things that cause pain and so there are things we can personally do to bring about relief. For instance, my knees were sore last night from too much oxylates from certain foods I'm over eating. I am cutting back on those and rubbing a magnesium oil into them at bedtime. That should help without the prescription pain killers, antiinflammatories and injectable steroids that all cause joint degregation and make them arthritic. The step after that is knee amputation ("replacement surgery") for a large percentage who go through the medical protocol for most. I am taking steps at the early onset to build them by God's grace.
I will post this video for you and your Grandma. It might not apply to her if she's not on meds and doesn't eat foods with flour. It might be informative though. If you go to Dr Osborne 's channel there is a long list of topics that might help at no charge.
Therefore, as God's chosen people, holy and dearly loved, clothe yourselves with compassion, kindness, humility, gentleness and patience.
—Colossians 3:12