In my case, I've always been really bad with numbers, so chapter and verse references don't work well for me. Words and phrases stick in my head really well, though. Being able to type in a verse and have the passage pop up is hugely beneficial for me. Also being able to copy and paste verses quickly is great!
I've got an app on my phone too, which is great, being able to carry the Bible with me anywhere conveniently.
e-Sword has a ton of features, I'm not sure about audio though. On a computer at least, if you need it, you could set up Windows accessibility options to have the computer read it for you, I'm sure.