Rule #1 Know the SOURCE of your INFORMATION DURING this BIBLICAL INFORMATION WARFARE!!!
STOP LISTENING to ANYTHING that has been TAINTED by the WHO or the CDC!!!
Make note of the CAUSE, TRANSMISSION and TREATMENTS BEFORE the DS attempts to CONSEAL & LIE just as they did with GROSSLY OVER EXAGERATING the LETHALITY of COVID and HIDING the CHEAP over the counter cures like Ivermectin and Hydroxychloroquine!!
Not to Worry!!! The DS NO LONGER CONTROLS the NARRATIVE - their 2nd PLANDEMIC will FAIL!!!
FOOL me ONCE shame on YOU (WHO/CDC), FOOL me TWICE shame on YOU (FOOLS)!!!
Monkeypox: epidemiology, pathogenesis, treatment and prevention
Thousands of people around the world have been infected by the monkeypox outbreak in 2022, which followed several years of sporadic cases outside of Africa (United Kingdom,86,87,88 Singapore,89,90 Israel,91,92 United States93).
After May 2022, a large number of monkeypox patients were confirmed in non-endemic countries worldwide. This unusual outbreak promoting the WHO to declare monkeypox as an “evolving threat of moderate public health concern” on June 23. Furthermore, the WHO announced that monkeypox outbreaks in many countries and regions constitute a “Public Health Emergency of International Concern” (PHEIC) on July 23, 2022.114,115 Meanwhile, monkeypox prevention and treatment guidelines have been issued in several countries around the world.116 As of 13 September 2022, 57,995 monkeypox virus infections which were laboratory confirmed have been reported in >100 countries or regions across all six WHO regions13 (Fig. 1 and Table 1). Of these, a total of 18 deaths were reported in 9 countries.
According to previous reports, monkeypox virus was not previously been highly contagious.
Another unusual feature is that the large number of cases diagnosed with monkeypox are male, and a considerable part of patients have sex with men (MSM), ...
a study of samples from 528 confirmed cases outside endemic areas in Africa between April and June showed that 98% of patients were bisexual men or gay and 95% of those infected were suspected of transmission through sexual activity.179 A prospective cohort study in Spain indicated that 91.7% cases identifying as MSM in 181 monkeypox infection cases.18
Meanwhile, using a branching process transmission model, researchers showed that a small minority of people have disproportionately large numbers of partners, which could explain the continued increase in monkeypox patients among MSM population.182
Monkeypox virus spread model for assessing outbreak risk in a metropolitan area indicated that if transmission efficiency increases in the higher-risk group like gays and MSMs, broader populations may be affected.184 On the other hand, Bragezzi et al.185 conducted a meta-analysis to show that sexual contact is involved in 91% cases (total 124 cases). Notably, a recent study of 21,098 monkeypox cases (data from 41 countries, as of August 23, 2022) revealed that the vast majority were MSM, with a typical rash characteristic.186 Transmission was mainly through close contact during sexual activities. Overall, all these reports suggested that MSM was up to now the most frequently suspected route of transmission.173,175,187,188,189,190,191,192,193
Treatment
For most patients, treatment is symptomatic and supportive. Despite the fact that monkeypox has no specific treatment, smallpox antiviral drugs such as brincidofovir, tecovirimat, and cidofovir may have effect against monkeypox because of their similar genetics.258,304,305,306,307,308
Viral particles are assembled into intracellular mature viruses (MV), then stay in the cytoplasm as intracellular mature virions of released as extracellular enveloped viruses during cell lysis. MV can also wrap an additional envelope and attached to the cell membrane, then then release through exocytosis. Cidofovir and its prodrug brincidofovir inhibit the viral DNA polymerase during DNA replication. Tecovirimat targets the VP37 protein, which is vital for envelopment of intracellular mature virus with Golgi-derived membrane to form enveloped virus (EV), prevents the virus from leaving an infected cell, hindering the spread of the virus within the body
Tecovirimat
Tecovirimat (also known as TPOXX, ST-246), a small-molecule inhibitor of virus, is effective against orthopoxviruses both in vitro and in vivo, including vaccinia virus, camelpox virus, cowpox virus, mousepox virus, variola viruses, and monkeypox virus.
309 Tecovirimat targets the VP37 protein, inhibits the spread of viruses within the body by preventing them from leaving infected cells,
309,
310
Tecovirimat has a distinguished antiviral effect against the monkeypox virus lineage responsible for the 2022 outbreak in vitro.
318 Further, the effectiveness and safety of tecovirimat has been revealed in multiple animal studies.
319,
320,
321,
322,
323,
324
Brincidofovir
Brincidofovir (also known as CMX001 or Tembexa) is a lipid conjugate of the acyclic nucleotide phosphonate, cidofovir (CDV).
Brincidofovir has under gone numerous animal studies
328,
366,
367,
368,
369,
370,
371,
372,
373,
374 to demonstrate its antiviral efficacy against double-stranded DNA viruses including poxviruses such as monkeypox virus and is currently in human clinical investigations for treating other double-stranded DNA viruses (Table
3).