But that doesn't mean that we don't know it's evolution and can prepare for it.
You Want Proof Of Ivermectin Effectiveness ? Here It Is!
MAY 19, 2021 / BRIANPECKFORD
Front Line Covid 19 Critical Care Alliance.
One Page Summary of the Clinical Trials Evidence for Ivermectin in COVID-19
Ivermectin, an anti-parasitic medicine whose discovery won the Nobel Prize in 2015, has proven, highly potent, anti-viral and anti-inflammatory properties in laboratory studies. In the past 4 months, numerous, controlled clinical trials from multiple centers and countries worldwide are reporting consistent, large improvements in COVID-19 patient outcomes when treated with ivermectin. Our comprehensive scientific review of these referenced trials can be found on the Open Science Foundation pre-print server here: https://osf.io/wx3zn/.
Properties of Ivermectin
1) Ivermectin inhibits the replication of many viruses, including SARS-CoV-2, influenza, and others;
2) Ivermectin has potent anti-inflammatory properties with multiple mechanisms of inhibition;
3) Ivermectin diminishes viral load and protects against organ damage in animal models;
4) Ivermectin prevents transmission of COVID-19 when taken either pre- or post-exposure;
5) Ivermectin hastens recovery and decreases hospitalization and mortality in patients with COVID-19;
6) Ivermectin leads to far lower case-fatality rates in regions with widespread use.
Evidence Base Supporting the Efficacy of Ivermectin in COVID-19 as of January 11, 2021 (RCT’s = randomized controlled trials, OCT’s = observational controlled trials).
Every clinical trial shows a benefit, with RCT’s and OCT’s reporting the same direction and magnitude; nearly all are statistically significant.
Controlled trials studying the prevention of COVID-19 (8 trials completed)
• 3 RCT’s with large statistically significant reductions in transmission rates, a total of 774 patients
• 5 OCT’s with large statistically significant reductions in transmission rates, a total of 2,052 patients
Controlled trials in the treatment of both early and hospitalized COVID-19 patients (19 trials completed)
• 5 RCT’s with large, significant reductions in time to recovery or hospital length of stay, a total of 774 patients
• 1 RCT with a large, statistically significant reduction in rate of deterioration/hospitalization, total of 363 patients
• 2 RCT’s with significant decreases in viral load, days of anosmia, cough, or time to recovery, a total of 85 patients
• 3 RCT’s with large, significant reductions in mortality, a total of 695 patients
• 3 OCT’s with large, statistically significant reductions in mortality, a total of 1,688 patients
Number of Studies and Patients Among the Existing Clinical Trials of Ivermectin in COVID-19
• 27 controlled trials, including a total of 6,612 patients have been completed using well-matched control groups
• 16 trials, including over 2,500 patients, are prospective, randomized, controlled studies
• 11 of the 27 trials have been published in peer-reviewed journals, 3,900 patients, remainder are in pre-print
Front Line COVID-19 Critical Care Alliance – Recommendation on Ivermectin in COVID-19
Even restricting analysis to just the 16 randomized controlled trials (totaling over 2,500 patients), the majority report a statisti- cally significant reduction in transmission or disease progression or mortality. Further, a meta-analysis recently performed by an independent research consortium calculated the chances that ivermectin is ineffective in COVID-19 to be 1 in 67 million.1
The FLCCC Alliance, based on the totality of the existing evidence, supports an A-I recommendation (NIH rating scheme; strong level, high quality evidence) for the use of ivermectin in both the prophylaxis and treatment of all phases of COVID-19.
Furthermore, we encourage all regulatory agencies to review our manuscript detailing these studies above as well as the multiple population-wide “natural experiments” that occurred in numerous cities and regions after the initiation of ivermectin distribution programs.
The widespread use of ivermectin resulted in a significant reduction in cases and mortality rates that approached pre-pandemic levels in these areas. As evidenced by what occurred in these regions, ivermectin is clearly an essential and vital treatment component in achieving control of the pandemic.
1 ivmmeta.com
2 Kory P, Meduri GU, Iglesias J, Varon J et al. Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and
Treatment of COVID-19. Open Science Foundation. https://osf.io/wx3zn/
For more information about the FLCCC Alliance, the I-MASK+ Prophylaxis & Early Outpatient Treatment
Protocol for COVID-19 and the MATH+ Hospital Treatment Protocol for COVID-19, please visit http://www.flccc.net
https://peckford42.wordpress.com/2021/05/19/you-want-proof-of-ivermectin-effectiveness-here-it-is/
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