I use this scripture in evangelism. If God justifies wicked men (and He does), is God an abomination to Himself? How is it that God can justify wicked men and not violate this text? These are some of the questions I ask folks before showing them how God is the justifier of the wicked and still remains just. Before I present this though, I show them how bad they really are. I show them how their wickedness permeates ever fiber of their being and their true need for a Saviour. And it is through this Saviour that God can justify wicked men and still be just. Sin HAS to be punished! God is not gonna just pass over our sin! Someone has to die, not bulls or goats like in times past, but it has to be a man! That man was Christ. God gave him over to be the punishment for the sin of His people.
That's the short (very short) form of how I use that scripture.
Eddie